The need to address the problems facing young people represents an enormous challenge to parents, health professionals and community leaders. Many groups and organizations have been working on these issues for years, often making important contributions for the children they serve. Yet the experience of several decades suggests that, with rare exception, none of these entities working alone is likely to have more than a marginal impact on a city's overall child health statistics. Generally, they have succeeded either in improving statistics in only a single, categorical area of concern or have succeeded in improving the health and safety of children in a small geographic area or neighborhood. None has been sufficiently broad based to significantly improve the health and safety of young people across an entire city or metropolitan area.

Community leaders have come to realize that real change requires a clear understanding of underlying causes of problems, a common vision of what to do to solve them, and a collective effort strategically carried out.

The purpose of the Robert Wood Johnson Foundation's Urban Health Initiative (UHI) is to determine whether a concerted, collaborative effort could bring about region-wide improvements in multiple measures of youth health and safety.

In May 1995, the Robert Wood Johnson Foundation invited community leaders in 20 cities to become involved in the initiative by applying for two-year planning-and-development grants. The Foundation requested that the applications be submitted in the form of a "single letter of interest" from each community. The process of preparing a single letter was designed to stimulate the establishment of "collaborative thinking" from the beginning, with organizations that may not have previously worked together agreeing to work together to craft a response.

Of the cities responding to the Foundation's challenge, eight were selected to receive funding. They were Baltimore, Chicago, Detroit, Miami, Oakland, Philadelphia, Richmond and Sacramento. Each site was provided with approximately $200,000 per year for two years of planning and development, with the knowledge that up to five of the eight sites would be funded for up to eight years of implementation.

The National Program Office was based at the University of Washington’s Evans School of Public Affairs until 2005.  At that time, the NPO became an independent 501(c)3 organization, The Institute for Community Change.

The Urban Health Initiative was designed to be non-prescriptive, allowing communities to craft implementation plans based on local conditions, without assumptions, mandates or imperatives set forward by the Foundation. Thus, during the two years of planning, each site was expected to identify local project leadership, build community collaboratives, establish priorities, select interventions and work with local communications consultants to design a communications strategy in concert with the development of an implementation plan. Site plans were submitted to the NPO on September 15, 1997.

The final five UHI sites--Baltimore, Detroit, Oakland, Philadelphia and Richmond--were selected in November 1997 following plan reviews and site visits. Grants averaging $1.2 million per year for four years were awarded to begin January 1, 1998. At the end of 2001, these communities were approved for an additional four years of Foundation funding.